Protein Molecular Weight Markers
ABclonal Technology CTRB1 Rabbit pAb
This gene encodes a serine protease that is a precursor of pancreatic proteolytic enzymes. The preproprotein is synthesized in the pancreas and secreted into the small intestine, where it is activated to form the functional enzyme. The CTRB1 gene is located head-to-head with the related CTRB2 gene. Some human populations have a haplotype with a 16.6 Kb inversion region, swapping portions of intron 1, exon 1, and upstream sequences between CTRB1 and CTRB2. This inversion is linked to differential gene expression and an increased risk of chronic pancreatitis. The GRCh38 assembly represents the minor allele for SNP rs8048956 in CTRB1. SNP rs8048956 in intron 1 of CTRB2 is diagnostic for the inversion. The CTRB1 gene encodes distinct isoforms, which may undergo similar processing to generate the mature protein.
ABclonal Technology RPRD1B Rabbit pAb
Enables RNA polymerase II complex binding activity and identical protein binding activity. Involved in positive regulation of cell population proliferation, regulation of cell cycle process, and regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of RNA polymerase II, holoenzyme.
ABclonal Technology PMEPA1 Rabbit pAb
This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
ABclonal Technology ZSCAN21 Rabbit pAb
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.
ABclonal Technology INCENP Rabbit pAb
In mammalian cells, centromere-interacting proteins are classified into two groups: constitutive and passenger proteins. Constitutive proteins, which bind centromere proteins, include CENPA, CENPB, CENPC1, and CENPD. Passenger proteins localize to the centromere during specific cell cycle stages and include CENPE, MCAK, KID, cytoplasmic dynein, CliPs, and CENPF/mitosin. Inner centromere proteins (INCENPs), early members of the passenger protein group, are broadly distributed along chromosomes in early mitosis but concentrate at centromeres during mid-metaphase. By telophase, they localize to the midbody in the intercellular bridge and are discarded after cytokinesis.
ABclonal Technology LPAR2 Rabbit pAb
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined.
ABclonal Technology pAbPC1 Rabbit pAb
This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3 poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation, it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.
ABclonal Technology StAR Rabbit pAb
The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13.
ABclonal Technology ACADS Rabbit pAb
This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with short-chain acyl-CoA dehydrogenase (SCAD) deficiency. Alternative splicing results in two variants which encode different isoforms.
ABclonal Technology SUGP2 Rabbit pAb
This gene encodes a member of the arginine/serine-rich family of splicing factors. The encoded protein functions in mRNA processing. Alternatively spliced transcript variants have been described.
ABclonal Technology LONP2 Rabbit pAb
In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
ABclonal Technology JAKMIP2 Rabbit pAb
The protein encoded by this gene is reported to be a component of the Golgi matrix. It may act as a golgin protein by negatively regulating transit of secretory cargo and by acting as a structural scaffold of the Golgi. Alternative splicing results in multiple transcript variants.
ABclonal Technology EDC4 Rabbit pAb
Predicted to be involved in deadenylation-independent decapping of nuclear-transcribed mRNA. Located in P-body and nucleoplasm.
ABclonal Technology ARPC2 Rabbit pAb
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined.
Stellar Scientific Enhanced 3-color High Range Protein Marker (9-245 kDa) 250uL x 2
The PM2610/PM2611 ExcelBand™ Enhanced 3-color High Range Protein Marker is a ready to use threecolor protein standard with 12 pre-stained proteins covering a wide range of molecular weights from 10 to 245 kDa in Tris-Glycine buffer (9 to 235 kDa in BisTris (MOPS) buffer and 10-235 kDa in Bis-Tris (MES) buffer).Proteins are covalently coupled with different chromophores for easy identification of bands, with two reference proteins carrying enhanced intensity corresponding to a green at 25 kDa and red at 75 kDa, respectively, as separated on SDS-PAGE (Tris-Glycine buffer).The ExcelBand™ Enhanced 3-color High Range Protein Marker is designed for monitoring protein separation during SDS-polyacrylamide gel electrophoresis, verification of Western transfer efficiency on membranes (PVDF, nylon, or nitrocellulose) and for approximating the size of proteins.
